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Teams looking to contend in the West clash when the Memphis Grizzlies visit the Los Angeles Lakers on Wednesday. Memphis is coming off a 134-89 win at Portland on Sunday, while Los Angeles defeated Toronto 123-103 that same night. The Grizzlies (7-4), who have won three in a row and five of six, are 3-2 on the road. The Lakers (6-4), who have won two straight, are 5-0 on their home court. Memphis will be without Desmond Bane (oblique) and Ja Morant (hip) due to injuries, while Marcus Smart (ankle) is questionable. Anthony Davis (foot) and D'Angelo Russell (illness) are probable for L.A.

Tip-off from Crypto.com Arena in Los Angeles is set for 10 p.m. ET. The Lakers lead the all-time regular-season series 66-41, but the Grizzlies earned a 131-114 win last week in Memphis. Los Angeles is a 7.5-point favorite in the latest Lakers vs. Grizzlies odds from SportsLine consensus, while the over/under for total points scored is 232.5. Before making any Grizzlies vs. Lakers picks, you'll want to see the NBA predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 4 of the 2024-25 NBA season on a sizzling 106-70 roll on all top-rated NBA picks dating back to last season, returning more than $3,000. Anyone following at sportsbooks and on betting apps has seen huge returns. 

The model has set its sights on Grizzlies vs. Lakers and just locked in its picks and NBA predictions. You can head to SportsLine now to see its picks. Here are several NBA betting lines for Lakers vs. Grizzlies:

  • Lakers vs. Grizzlies spread: Lakers -2.5
  • Lakers vs. Grizzlies over/under: 232.5 points
  • Lakers vs. Grizzlies money line: Lakers -305, Grizzlies +243
  • MEM: The Grizzlies have hit the money line in 20 of their last 42 road games (+20.60 units)
  • LAL: The Lakers have hit the Over in 44 of their last 75 games (+11.00 units)  
  • Lakers vs. Grizzlies picks: See picks at SportsLine
  • Lakers vs. Grizzlies streaming: FuboTV (Try for free)

Why the Lakers can cover

Small forward LeBron James continues to be the heartbeat of the Los Angeles offense. In 10 starts, he is averaging 23.2 points, 8.9 assists and 7.7 rebounds in 34.8 minutes. He is coming off back-to-back triple-doubles. In Sunday's win over the Toronto Raptors, he scored 19 points, dished out 16 assists and grabbed 10 rebounds. He added 21 points, 13 assists and 12 rebounds in Friday's 116-106 win over the Philadelphia 76ers.

Shooting guard Austin Reaves is one of five players averaging double-digit scoring. In 10 games, he is averaging 18.7 points, 5.2 assists, 4.5 rebounds and 1.4 steals in 34.3 minutes. Reaves is connecting on 48.5% of his field goals and 77.8% of his free throws. In Sunday's win over Toronto, he finished with a season-high 27 points and six assists. See which team to pick here.

Why the Grizzlies can cover

Power forward Jaren Jackson Jr. is among Memphis' top offensive options. In nine games, all starts, he is averaging 21.8 points, 5.4 rebounds, 1.4 steals, 1.2 blocks and one assist in 27.7 minutes. He has been red hot from the field, connecting on 55.4% of his field goals, including 40.9% from 3-point range, and 73.9% of his free throws. In a 128-104 win over Washington on Friday, he poured in 39 points and grabbed six rebounds.

Power forward Santi Aldama is one of eight players averaging 10 or more points. He has registered three double-doubles, including an 11-point and 12-rebound effort in the win over the Lakers last week. He scored a season-high 27 points in a 126-124 win over the Utah Jazz on Oct. 23. For the season, he is averaging 12.8 points, 7.6 rebounds and 3.7 assists in 30.1 minutes. See which team to pick here.

How to make Grizzlies vs. Lakers picks

The model has simulated Grizzlies vs. Lakers 10,000 times and the results are in. The model is leaning Under on the total, projecting 225 combined points. It also says one side of the spread hits well over 50% of the time. You can only see the pick at SportsLine.

So who wins Grizzlies vs. Lakers, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Grizzlies vs. Lakers spread you need to jump on, all from the model that is on a 106-70 roll on top-rated NBA picks, and find out.